Dr. No was the first James Bond film. Based on the 1958 novel of the same name by Ian Fleming, it was adapted by Richard Maibaum, Johanna Harwood, and Berkely Mather and was directed by Terence Young. The film was produced by Harry Saltzman and Albert R. Broccoli, a partnership that would continue until 1975.
John Strangways, the British Intelligence (SIS) Station Chief in Jamaica, is ambushed and killed, and his body taken by a trio of assassins known as the "Three Blind Mice". In response, British agent James Bond (Secret Agent 007) is summoned to the office of his superior, M. Bond is briefed to investigate Strangways' disappearance and to determine whether it is related to his cooperation with the American Central Intelligence Agency (CIA) on a case involving the disruption of rocket launches from Cape Canaveral by radio jamming.
Upon his arrival at Kingston Airport, a female photographer tries to take Bond's picture and he is shadowed from the airport by two men. He is picked up by a chauffeur, whom Bond determines to be an enemy agent. Bond instructs him to leave the main road and, after a brief fight, Bond starts to interrogate the driver, who then kills himself with a cyanide-embedded cigarette.
During his investigation in Strangways' house Bond sees a photograph of a boatman with Strangways. Bond locates the boatman, named Quarrel, but finds him to be un-cooperative. Bond also recognises Quarrel to have been the driver of the car that followed him from the airport. Bond follows Quarrel and is about to be beaten by him and a friend when the fight is interrupted by the second man who followed Bond from the airport: he reveals himself to be CIA agent Felix Leiter and explains that not only are the two agents on the same mission but also that Quarrel is helping Leiter. The CIA has traced the mysterious radio jamming of American rockets to the vicinity of Jamaica, but aerial photography cannot determine the exact location of its origin. Quarrel reveals that he has been guiding Strangways around the nearby islands to collect mineral samples. He also talks about the reclusive Dr. No, who owns the island of Crab Key, on which there is a bauxite mine: the island and mine are rigorously protected against trespassers by an armed security force and radar.
During a search of Strangways' house, Bond found a receipt, signed by Professor R. J. Dent, concerning rock samples. Bond meets with Dent who says he assayed the samples for Strangways and determined them to be ordinary rocks. This visit makes Dent wary and he takes a boat to Crab Key where Dr. No expresses displeasure at Dent's failure to kill Bond and orders him to try again, this time with a tarantula. Bond survives and after a final attempt on his life, sets a trap for Dent, whom he captures, interrogates and then kills.
Having detected radioactive traces in Quarrel's boat, where Strangways' mineral samples had been, Bond convinces a reluctant Quarrel to take him to Crab Key. There Bond meets the beautiful Honey Ryder, dressed only in a white bikini, who is collecting shells. At first she is suspicious of Bond but soon decides to help him, leading them all inland to an open swamp. After nightfall they are attacked by the legendary "dragon" of Crab Key which turns out to be a flame-throwing armoured tractor. In the resulting gun battle, Quarrel is incinerated by the flame-thrower whilst Bond and Ryder are taken prisoner. Bond and Ryder are decontaminated and taken to quarters before being drugged.
Upon waking they are escorted to dine with Dr. No. He reveals that he is a member of SPECTRE (SPecial Executive for Counter-intelligence, Terrorism, Revenge, and Extortion) and plans to disrupt the Project Mercury space launch from Cape Canaveral with his atomic-powered radio beam. After dinner Ryder is taken away and Bond is beaten by the guards.
Bond is imprisoned in a holding cell but manages to escape through a vent. Disguised as a worker, Bond finds his way to the control centre, a multi-level room full of high-tech instrumentation with an atomic reactor set into the floor, overseen by Dr. No from a command console. Bond overloads the nuclear reactor just as the American rocket is about to take off. Hand-to-hand combat ensues between Bond and Dr. No; the scientist is pushed into the reactor's cooling vat, in which he boils to death. Bond finds Ryder and the two escape in a boat just as the entire lair explodes.